viagra gold 800 mg Eur > medicine & health > erasmus mc > dijkzigt > surgery > view article pubmed: 19328572 scopus: 66949172038 multimodality treatment for anaplastic thyroid carcinoma - treatment outcome in 75 patients swaak-kragten, a. T. Wilt, j. H. W. De schmidtz, p. I. Bontenbal, m. Levendag, p. generic viagra online cheap generic viagra india viagra without a doctor prescription viagra online buy generic viagra viagra online generic viagra C. July 2009 article radiotherapy & oncology volume 92, issue 1 pp 100-104. Surgery / radiotherapy repository contains one file which is not publicly available purpose: to retrospectively analyze the outcome of patients with anaplastic thyroid carcinoma (atc) treated in the erasmus mc. Material and methods: seventy-five atc-patients were treated between 1972 and 2003. Mean age was 68 years. Tumor stage was iva in 9%, ivb in 51%, and ivc in 40%. Thirty-six patients underwent up-front surgery, with 53% resulting in r0/r1 resection. Before 1988 adjuvant treatment consisted of conventional radiotherapy (rt) and/or chemotherapy (ct). As of 1988, 30 eligible patients were enrolled in a newly designed protocol. This consists of locoregional rt in 46 fractions of 1. 1 gy, given twice daily, followed by prophylactic irradiation of the lungs (pli) in 5 daily fractions of 1. 5 gy. During radiation, low-dose doxorubicine (15 mg/m2) is administered weekly and is followed by adjuvant doxorubicine (50 mg/m2) 3-weekly up to a cumulative dose of 550 mg/m2. Twenty-five ineligible patients were treated conventionally. Results: overall median survival was 3 months, 1-year os 9%. Locoregional control was significantly higher in patients who had undergone r0/r1 resection or chemoradiation, with best results for patients who underwent both (complete remission in 89%). However, the survival benefit of patients who reached cr remained borderline (median os 7 months, 1-year os 32%). Three patients survived for more than 5 years; all had undergone r0/r1 surgical resection and chemoradiation. Acute toxicity in the protocol group was significantly higher than in the nonprotocol group, with 46% versus 11% grade 3 pharyngeal and/or esophageal toxicity. Conclusion: despite the ultimately dismal prognosis of atc-patients, multimodality treatment significantly improved local control and improved the median survival. Keywords survival local control anaplastic thyroid carcinoma hyperfractionated radiotherapy multimodality therapy prophylactic lung irradiation bookmark with: citeulike bibsonomy mendeley reference manager web page, plain style web page, apa style web page, chicago style word 2007 xml bibliography bibtex repub, 2012 repub all publications all dissertations search the repository browse by classification recently added browse b.